Outcomes of pallidal deep brain stimulation for treating pure blepharospasm

Objective: Blepharospasm (BSP) is a disease in which the closure rate of bilateral eyelids increases, mainly due to involuntary contraction orbicularis oculi, procerus, and corrugator muscles. The objective this study was report postoperative outcomes after deep brain stimulation (DBS) 10 cases pure BSP at least 12 months follow-up.Methods: Ten patients with who underwent globus pallidus interna (GPi) DBS Catholic University Korea, Incheon St. Mary’s Hospital, between 2019 2021 were included. Burke-Fahn-Marsden dystonia rating scale (BFMDRS), Disability Index, Jankovic Rating Scale used for analysis before surgery, 6 follow-up as short-term outcomes, over 1 year (12–37 months) long-term results. Results: median age surgery 56.5 years (interquartile range [IQR], 50.5–65.8 years) length time from onset 58.0 (IQR, 46.8–64.3 months). period 22.5 15.3–29.0 BFMDRS movement subscale scores three points (preoperative baseline, months, follow-up) 7.0 6.0–8.0), 4.5 3.9–6.0; 35.7% improvement, p<0.001), 3.8 2.8–5.3; 45.7% p=0.002), respectively.Conclusion: Bilateral GPi can be effective if conservative treatment options fail. Its benefit not only observed short term, but also maintained during follow-up.